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What over the counter drug is equivalent to pantoprazole? Protonix is available by prescription while Prilosec is available over-the-counter (OTC) and as a generic. Is Protonix stronger than omeprazole? Protonix (pantoprazole) Treats heartburn and excess release of stomach acid. Prilosec (omeprazole) gives you long-lasting heartburn relief but has some risks if used long term. Treats heartburn and excess release of stomach acid.
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