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With a given dose of mycophenolic acid (MPA) products, exposure to MPA is higher with tacrolimus co-administration than with cyclosporine co-administration because cyclosporine interrupts the enterohepatic recirculation of MPA while tacrolimus does not.

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Following transplantation (Day 0), patients received Tacrolimus BID or Tacrolimus QD, together with matched placebo for the alternative formulation, in combination with low-dose MMF and corticosteroids.

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